Stream 3: Discovery Science #10

Tracks
Meeting Room 105 & 106
Friday, August 21, 2026
2:00 PM - 3:30 PM
Meeting Room 105 & 106 (Level 1)

Speaker

Ms Li Ern Yap
PhD Candidate
University of Sydney

Regulated mobilisation of a sequestered GLUT4 pool is selectively impaired in insulin resistance

2:50 PM - 3:05 PM

Biography

Li Ern is a second-year PhD candidate in the David James Lab at The University of Sydney. Her research aims to uncover the molecular mechanisms that cause selective impairments in GLUT4 trafficking, a key process disrupted in insulin resistance.
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Dr Simon Bond
Research Officer
The Baker Heart and Diabetes Institute

Chronic mtDNA damage drives muscle wasting through sustained integrated stress response activation and one-carbon metabolic rewiring

3:05 PM - 3:20 PM

Biography

Dr Simon Bond is a cardiometabolic disease researcher investigating the molecular mechanisms underlying mitochondrial dysfunction and activation of the Integrated Stress Response. His work integrates novel pre-clinical models with mechanistic approaches to elucidate maladaptive stress signalling in cardiometabolic disease and identify potential therapeutic targets.
Simran Singh
Ph.d.
IIT Kanpur

Macrophage GPR18 signaling suppresses β-cell insulin secretion via a Gq-AMPK-sphingolipid pathway

3:20 PM - 3:35 PM

Biography

Simran Singh is a PhD researcher in metabolic immunology studying macrophage–β-cell communication in obesity and diabetes. Their work focuses on GPCR signaling, lipid mediators, and immune regulation of pancreatic islet function to understand mechanisms underlying β-cell dysfunction in metabolic disease.
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