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GSK Breakfast Symposium - More than meets the eosinophil: the evolving science of interleukin-5 in airway type-2 inflammation

Sunday, March 23, 2025
7:15 AM - 8:15 AM
E1
Sponsored By:
GSK

Details

Interleukin-5 (IL-5) is well known for its critical role in eosinophil generation, activation and survival, and therefore has been a therapeutic target in Type 2 inflammatory airways disease. This symposium aims to delve into the emerging evidence demonstrating multifaceted roles of IL-5 beyond its traditional understanding. Hear from internationally renowned experts on the evidence demonstrating the potential impact IL-5 has on epithelial barrier integrity, immune cell dysfunction and airway remodelling, presented in the context of clinical practice and anti-IL-5 intervention in airways disease. Join us for this enlightening symposium to stay at the forefront of IL-5 research and its transformative potential in managing Type 2 inflammatory diseases.


Speaker

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Prof Gary Anderson
Director, Lung Health Research Centre
University of Melbourne

More than meets the eosinophil: The evolving science of interleukin-5 in airway type-2 inflammation

7:15 AM - 8:15 AM

Biography

Gary Anderson works in translational immunopharmacologynusing genetic disease models and clinical cohorts to find molecular mechanisms of lung diseases, especially asthma and COPD. He described the diffusion microkinetic mechanism of long-acting beta-2 agonists and the critical role of IL-4 in murine Th2/T2 lung immunity. In 2008 he proposed the widely adopted “Endotype” concept of disease. His work identified the pathogenic role of SAA, gp130 and the Src family kinases LYN and HCK in lung disease. Earlier, he worked in the Swiss pharma industry and contributed to the discovery and development of the clinical medicines formoterol, indacaterol, omalizumab/anti-IgE and imatininb. His current work on drug development includes otilimab/anti-GM-CSF, elarekibep/PRS-060/AZD1472 anticalin and new inhaled JAG-1 blockers for muco-obstructive disease. He was a co-author of the Lancet Commission on asthma and leads the CURE Asthma initiative.
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Prof Philip Bardin
Professor, Monash Lung Sleep Allergy & Immunology
Monash Lung and Sleep

More than meets the eosinophil: The evolving science of interleukin-5 in airway type-2 inflammation

7:15 AM - 8:15 AM

Biography

Professor of Respiratory Medicine in the Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne, Australia. Emeritus Director, Lung Sleep Allergy & Immunology, Monash University and Medical Centre, Melbourne. 2008 -2024. Phil is a practising clinician recognised for research of obstructive lung diseases (particularly asthma-COPD). Conducted extensive research of new asthma and COPD therapies. Recently studies have included vocal cord dysfunction/inducible laryngeal obstruction (VCD/ILO), an important and common but neglected condition. Recipient of ongoing Australian NH&MRC funding and has chaired the Australian NH&MRC Grant Review Panel (Respiratory & Sleep Medicine) and served on the NH&MRC Academy. Immediate past-Co-Editor-in-Chief of Respirology, official journal of the TSANZ and APSR. These professional activities reflect a career-long commitment to clinical research, teaching, administration and medical publishing.
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Dr Angela Moran
Respiratory Physician
Te Whatu Ora Health

More than meets the eosinophil: the evolving science of interleukin-5 in airway type-2 inflammation

7:15 AM - 8:15 AM

Biography

Dr Angela Moran is a Respiratory Physician at Christchurch Hospital. She completed a Clinical Research Fellowship with Prof Ian Pavord at the University of Oxford/Oxford NHS Trust Hospitals, where she was an integral member of the Severe Asthma Service. She has extensive experience using biologic therapies to treat severe eosinophilic asthma. Dr Moran has authored a number of publications on asthma and COPD and has presented her research at various international meetings. She enjoys utilising her skills in the Canterbury community as an asthma specialist.
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