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Workshop 11: The renaissance of placental perfusion models to understand placental transport and toxicology

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Session Name
Friday, September 8, 2023
1:30 PM - 3:30 PM
Mansfield Room

Details

Organisers: A/Prof Christian Wadsack (University of Graz, Austria) Dr Birgit Hirschmugl (University of Graz, Austria) Aim: Since the development of the ex vivo dual perfusion model of the human placenta cotyledon, the technique has provided essential insight into how nutrients, lipids, gases, immunoglobulins, endocrine agents, pharmaceuticals, chemicals, nanoparticles, micro-organisms and parasites might traverse the maternofetal barrier. Moreover, the model has been essential in gaining a better understanding of the regulation of vascular tone, endocrinology and metabolism within this organ. In this workshop we will briefly present the advantages of the method in different fields of application. After this short introduction, we will discuss in small groups how complementary models as well as theoretical modelling might be complementary tools for a better understanding on the effect of toxic substances on the placenta and unborn. 1330-1340: Introduction - A/Prof Christian Wadsack 1340-1345: Dr Tina Buerki-Thurnherr 1345-1350: Miss Paulina Fuentes 1350-1355: Prof Christiane Albrecht and Dr Rona Karahoda 1355-1400: Prof František Štaud 1400-1405: Prof Rohan Lewis 1405-1410: Prof. Stefan Hansson and Dr Birgit Hirschmugl 1410-1415: Dr Michelle Broekhuizen 1415-1510: Discussion in small focus groups 1510-1530: Close


Speakers

Dr Tina Buerki-Thurnherr
Group Leader
EMPA

Complementing placental perfusion with a human-based placenta-embryo chip model

1:40 PM - 1:45 PM
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Miss Paulina Fuentes
PhD Student
Placenta Lab

Ex-vivo human placental perfusion as a model for evaluating placental transfer of PETN to prevent Intrauterine Growth Restriction

1:45 PM - 1:50 PM
Prof Christiane Albrecht
University of Bern, Institute of Biochemistry and Molecular Medicine

Profiling of steroid hormone species in ex-vivo and in-vitro human placental models

1:50 PM - 1:55 PM
Dr Rona Karahoda
Assistant Professor
Charles University

Profiling of steroid hormone species in ex-vivo and in-vitro human placental models

1:50 PM - 1:55 PM
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Prof František Štaud
Full Professor
Charles University

Perfused rat term placenta as a preclinical model to investigate placental homeostasis of monoamines

1:55 PM - 2:00 PM
Prof Rohan Lewis
Professor
University of Southampton

How to design a perfusion experiment to obtain the maximum benefit from mathematical modelling

2:00 PM - 2:05 PM
Prof Stefan Hansson
Lund University

The impact of air pollution particles on placental structure and function

2:05 PM - 2:10 PM
Dr Birgit Hirschmugl
PI
Medical University of Graz

The impact of air pollution particles on placental structure and function

2:05 PM - 2:10 PM
Dr Michelle Broekhuizen
Postdoctoral
Erasmus MC

Placental transfer and metabolism of betamethasone in healthy and preeclamptic human placentas

2:10 PM - 2:15 PM
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