Workshop 11: The renaissance of placental perfusion models to understand placental transport and toxicology
Tracks
Session Name
Friday, September 8, 2023 |
1:30 PM - 3:30 PM |
Mansfield Room |
Details
Organisers:
A/Prof Christian Wadsack (University of Graz, Austria)
Dr Birgit Hirschmugl (University of Graz, Austria)
Aim:
Since the development of the ex vivo dual perfusion model of the human placenta cotyledon, the technique has provided essential insight into how nutrients, lipids, gases, immunoglobulins, endocrine agents, pharmaceuticals, chemicals, nanoparticles, micro-organisms and parasites might traverse the maternofetal barrier. Moreover, the model has been essential in gaining a better understanding of the regulation of vascular tone, endocrinology and metabolism within this organ.
In this workshop we will briefly present the advantages of the method in different fields of application. After this short introduction, we will discuss in small groups how complementary models as well as theoretical modelling might be complementary tools for a better understanding on the effect of toxic substances on the placenta and unborn.
1330-1340: Introduction - A/Prof Christian Wadsack
1340-1345: Dr Tina Buerki-Thurnherr
1345-1350: Miss Paulina Fuentes
1350-1355: Prof Christiane Albrecht and Dr Rona Karahoda
1355-1400: Prof František Štaud
1400-1405: Prof Rohan Lewis
1405-1410: Prof. Stefan Hansson and Dr Birgit Hirschmugl
1410-1415: Dr Michelle Broekhuizen
1415-1510: Discussion in small focus groups
1510-1530: Close
Speakers
Dr Tina Buerki-Thurnherr
Group Leader
EMPA
Complementing placental perfusion with a human-based placenta-embryo chip model
1:40 PM - 1:45 PM
Miss Paulina Fuentes
PhD Student
Placenta Lab
Ex-vivo human placental perfusion as a model for evaluating placental transfer of PETN to prevent Intrauterine Growth Restriction
1:45 PM - 1:50 PM
Prof Christiane Albrecht
University of Bern, Institute of Biochemistry and Molecular Medicine
Profiling of steroid hormone species in ex-vivo and in-vitro human placental models
1:50 PM - 1:55 PM
Dr Rona Karahoda
Assistant Professor
Charles University
Profiling of steroid hormone species in ex-vivo and in-vitro human placental models
1:50 PM - 1:55 PM
Prof František Štaud
Full Professor
Charles University
Perfused rat term placenta as a preclinical model to investigate placental homeostasis of monoamines
1:55 PM - 2:00 PM
Prof Rohan Lewis
Professor
University of Southampton
How to design a perfusion experiment to obtain the maximum benefit from mathematical modelling
2:00 PM - 2:05 PM
Prof Stefan Hansson
Lund University
The impact of air pollution particles on placental structure and function
2:05 PM - 2:10 PM
Dr Birgit Hirschmugl
PI
Medical University of Graz
The impact of air pollution particles on placental structure and function
2:05 PM - 2:10 PM
Dr Michelle Broekhuizen
Postdoctoral
Erasmus MC