Dr. Gupta is an Associate Professor of Medicine at Harvard Medical School, Associate Member at the Broad Institute and cardiologist at Brigham and Women’s Hospital. His research links human genetic variation to novel mechanisms of gene regulation and cardiovascular disease. His laboratory has led efforts to apply high-through cellular genetic screens, such as Perturb-seq, to identifying the pathways which link multiple genetic risk loci. Dr. Gupta completed a post-doctoral fellowship in Human Genetics at the Broad Institute with David Altschuler and Sekar Kathiresan, and clinical training in cardiology at Brigham and Women’s Hospital and Massachusetts General Hospital. He graduated from the University of Pennsylvania School of Medicine, where he received the Adolf Creskoff Prize. He has been awarded research grants from the National Institutes of Health, the Chan Zuckerberg Institute, and the Broad Institute. Dr. Gupta is the recipient of the 2019 New Innovator Award from the NIH Director for his project, “A Genetic Approach to Identify the Common Mechanisms of Vascular Disease.” Dr. Gupta’s clinical practice focuses on the genetics of rare vascular disorders, such as genetic aortic disease and cerebrovascular malformations, as well as the use of polygenic risk scores to guide prevention of atherosclerosis in patients with high genetic risk.

Dr. Pradeep Natarajan is the Director of Preventive Cardiology and the Paul and Phyllis Fireman Endowed Chair in Vascular Medicine at Massachusetts General Hospital, Associate Director of Personalized Medicine at Mass General Brigham, Associate Professor of Medicine at Harvard Medical School, and Associate Member of the Broad Institute of Harvard and MIT. His research program spans the MGH Cardiovascular Research Center, MGH Center for Genomic Medicine, and Broad Institute of Harvard and MIT. He uses germline and somatic genetic variation to uncover new biology and enable enhanced clinical care for cardiovascular disease. He leads several consortia to use genetic epidemiology, large-scale sequencing studies, genotype-driven human investigation, and genetic testing implementation. He is an Associate Editor for JAMA Cardiology and Science Advances. He is an elected member of the American Society for Clinical Investigation and the Association of American Physicians. He has been awarded the Jeffrey M. Hoeg and Joseph A. Vita Awards by the American Heart Association for his contributions. In tandem with his research efforts, Dr. Natarajan oversees clinical and training programs on the prevention of cardiometabolic diseases leading the MGH Cardiovascular Disease Prevention Center, and health system-wide innovative clinical paradigms via the MGB Personalized Medicine.

Eleni Giannoulatou leads the Computational Genomics Group at the Victor Chang Cardiac Research Institute. Her research focuses on identifying the underlying genetic determinants and causes of cardiovascular disease. Eleni received her Doctor of Philosophy in Bioinformatics from the University of Oxford, UK in 2011. She undertook postdoctoral work at the Wellcome Trust Centre for Human Genetics in Oxford and the Weatherall Institute of Molecular Medicine in Oxford. Eleni holds an NHMRC Investigator Grant and is an Honorary Heart Foundation Future Leader fellow.

A/Professor Emily Wong is the Faculty and Head of the Regulatory Systems Laboratory at the Victor Chang Cardiac Research Institute (VCCRI). She completed her Ph.D. in comparative genomics at the University of Sydney. She trained at the EMBL-European Bioinformatics Institute in Cambridge, UK, in regulatory genomics and, at the University of Queensland. Emily established her group at VCCRI, focusing on understanding the rules underlying mammalian gene regulation. She holds an NHMRC Investigator Grant and a Snow Medical Fellowship.

Zornitza is a clinical geneticist at the Victorian Clinical Genetics Services and Clinical Lead, Australian Genomics. Since 2014, Zornitza has played a leadership role in numerous translational genomics projects through Melbourne Genomics, Australian Genomics, and the Genomics Health Futures Mission, all aimed at accelerating rare disease diagnosis. She has co-authored over 240 manuscripts, and has attracted over $60M in research funding.

Sonia is a Group Leader and Heart Foundation Future Leader Fellowship based at the Institute for Molecular Bioscience, The University of Queensland. Her research uses large-scale genomics and health data to improve the understanding of cardiovascular disease, with the goal to improve disease prevention and facilitate drug discovery. Her previous research uncovered a polygenic contribution in Familial Hypercholesterolemia, and she co-led the first large-scale genetic study of heart failure. Her current research is focused on addressing the diversity gap in cardiovascular research, with a focus on understanding risk in women, and she leads the South Asian Genes and Health in Australia study. She is the recipient of the Australian Academy of Science Ruth Stephens Gani Medal for her contribution to genetics research.