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THANZ: Venous thrombosis and fibrinolysis - basic mechanisms and therapeutic opportunities

Tracks
THANZ
Tuesday, November 7, 2023
4:00 PM - 5:00 PM
Meeting room 219

Speaker

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Prof Nicola Mutch
University of Aberdeen

Cellular regulation of fibrinolysis

4:00 PM - 4:20 PM

Biography

Prof Nicola Mutch is a Personal Chair University of Aberdeen, Scotland. She carried out her undergraduate and postgraduate studies at the University of Aberdeen specialising in haemostasis, thrombosis and vascular biology. She subsequently moved to the University of Illinois for a post-doctoral position for 4 years before returning to her first independent position in Cardiovascular Biology at The University of Leeds. She was awarded a personal fellowship from the British Heart Foundation and returned to the University of Aberdeen in 2012 to pursue her work and build an independent group. Prof Mutch research interests focus on the physiological and pathological mechanisms underpinning haemostasis, thrombosis and vascular biology by employing a translational approach from basic protein biochemistry to modelling thrombosis and patient-based studies. The overarching goal is to understand the mechanisms and drivers underpinning these cardiovascular and immunothrombotic diseases to develop and define more appropriate and personalised treatment strategies.
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Prof Ross Baker
Haematologist
Perth Blood Institute / Murdoch University

Thrombolysis and pulmonary embolism

4:20 PM - 4:40 PM

Biography

Professor Ross Baker is a practising consultant haematologist and clinical researcher. As Principal Investigator in over 125 large international phase II and III clinical trials, he has contributed to a change of practice in haematology through clinical research in venous thrombosis, leukaemia, lymphoma, myeloma, thrombocytopenia, Von Willebrand disease and haemophilia. He has authored over 127 papers in peer-reviewed medical journals with high-impact factor and has been a regularly invited speaker at international and national medical meetings. He is a founding director and secretary of the Australasian Society for Thrombosis and Haemostasis (ASTH now THANZ), Founding Chair of the Perth Blood Institute and scientific advisor to the World Health Organisation on DVT in 2001. Currently, he is Chair of the International Society of Thrombosis and Haemostasis Von Willebrand Subcommittee, expert advisor on the Venous Thrombo-embolism Committee of National COVID-19 Clinical Evidence Taskforce, Editorial Board Member of Blood, the Journal of the American Society of Hematology, Australian representative on the Asian Pacific Thrombosis and Haemostasis Society Council, member of Australian Haemophilia Centre Directors Organisation and Study Chairman of 2 large academic collaborative studies (Thrombosis and Haemostasis Society of Australia and New Zealand (THANZ) new oral anticoagulant Reversal and Event Collaborative (ARES) and the Asian Pacific Microangiopathic Thrombocytopenia Network (APMAT). He has enthusiasm for teaching medical and science students and supervises postgraduate PhD, Masters and Honours research students. He supervises the Regional Training Scheme Program of the International Society of Thrombosis and Haemostasis with Malaysia for specialist clinical and research training and mentoring. He initiated medical science encounter days for promising year 11 and 12 high school students to have hands-on experience in a research laboratory so they may discover the power of science. His current science research interests include microRNA control of coagulation factors, platelet receptor function, and ADAMTS 13 testing and regulation. He also serves as Chairman of the Perth Blood Institute, Director of the Haemophilia Treatment Centre and Senior Clinical Haematologist at Hollywood Hospital, Director of the WA Centre for Thrombosis and Haemostasis, Murdoch University and Director of Medical Services at Western Haematology and Oncology Clinics.
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Dr Cherry Keragala
Haematologist
Monash Health

Fibrinolysis and plasminogen activation in thrombolysis and potential outcomes

4:40 PM - 5:00 PM

Biography

Dr Charithani (Cherry) Keragala is an early career clinician-scientist and haematopathologist at Monash Health/Victorian Heart Hospital and recently completed her PhD at the Australian Centre for Blood Diseases at Monash University in 2023. She has been a fellow of the Royal College of Pathologists of Australasia and the Royal Australasian College of Physicians since 2018. She is an adjunct lecturer in Medicine at Monash Health, School of Clinical Sciences. Dr. Keragala’s PhD explores the relationship between the fibrinolytic system and the innate immune response combining both basic science research and clinical trial data. Dr. Keragala is an associate editor of ‘Thrombosis Journal’; the flagship journal of the Asia-Pacific Society of Thrombosis and Haemostasis and the current secretary of the Thrombosis and Haemostasis Society of Australia and New Zealand. Dr. Keragala is also part of the media-based learning subcommittee of the International Society for Thrombosis and Haemostasis and has recently been appointed to the International Society for Fibrinolysis and Proteolysis Council. As a young female early career clinician-researcher and mother, Dr. Keragala is passionate about women in STEM and is a member of the Gender Equity in Medicine Reference Group for the RACP.

Chairperson

Ashwini Bennett
Haematologist
Monash Health

Robert Medcalf
Laboratory Director
Monash University

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